Extracranial carotid disease (carotid stenosis) accounts for at least 50% of ischemic strokes and should be managed efficiently to minimize the incidence of stroke. The carotid arteries, located in the neck, are the major source of oxygen-rich blood flow to the brain. Carotid artery stenosis (CAS) occurs when these arteries become thick and more narrow, hence cutting off some of this necessary blood supply. Carotid intervention (endarterectomy or stenting, depending on the clinical setting) is recommended generally in symptomatic patients with stenosis of more than 70% and in selected asymptomatic. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial Description: The purpose of this trial is to determine the most effective treatment method to prevent strokes in people who have narrowing in the carotid artery but no stroke symptoms caused by the blockage of that artery. Carotid artery disease is also called carotid artery stenosis. The term refers to the narrowing of the carotid arteries. This narrowing is usually caused by the buildup of fatty substances and. The extracranial to intracranial bypass trial, 51 undertaken in the 1980s, was a prospective, international, multicentre, randomised trial comparing extracranial to intracranial bypass (superficial temporal artery to the middle cerebral artery) and medical therapy in 1377 patients with extracranial carotid occlusion or intracranial carotid or middle cerebral artery stenosis. What is the best antithrombotic therapy for patients with atrial fibrillation and severe internal carotid artery stenosis? Definition. Carotid artery stenosis (CAS), atherosclerotic narrowing of the extracranial carotid arteries, is clinically significant because CAS is a risk factor for ischemic stroke, which affects more than 600,000 American adults each year. Background: Several mechanisms contribute to the increased stroke rate of patients with atrial fibrillation (AF). We assessed the frequency of carotid artery stenosis in patients with AF and its relationship to stroke during aspirin or warfarin therapy. Atherosclerotic intracranial arterial stenosis is an important cause of stroke. Warfarin is commonly used in preference to aspirin for this disorder, but these therapies have not been compared in.